Sodium Hydroxide → 1-(2,4-Dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanol

HRID 1649781

Reaktionsgleichung

Reaktionsgleichung von HRID 1649781
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([OH:16])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[OH-:17].[Na+].[Cl:19][C:20]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:21]=1[O:22][CH2:23][CH2:24]Br>C1(C)C=CC=CC=1.[Cl-].C([N+](CCCCCCCCCCCC)(C)C)C1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([O:17][CH2:24][CH2:23][O:22][C:21]1[CH:26]=[CH:27][C:28]([Cl:30])=[CH:29][C:20]=1[Cl:19])([OH:16])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1

Komponenten

6

Edukt 3

HCID 14798Sodium HydroxideHCID 1388811-(2-Bromoethoxy)-2,4-dichlorobenzeneHCID 66285758905-18-3

Produkt 1

HCID 540910161-(2,4-Dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanolAusbeute 35 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8753Benzododecinium ChlorideKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

12.95 g (0.05 mole) of 1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-1-ethanol are dissolved in 100 ml of toluene, and 100 ml of 40% strength sodium hydroxide solution and 1 ml of benzyl-dodecyl-dimethylammonium chloride are added. 13.5 g (0.05 mole) of 2,4-dichlorophenoxyethyl bromide are then added dropwise and the mixture is subsequently stirred at room temperature for 48 hours. The organic phase is separated off, washed with three 100 ml portions of saturated sodium chloride solution, dried over sodium sulphate and concentrated. The residue is taken up in 100 ml of diethyl ether, and crystallizes after the mixture has stood for a short time. 7.8 g (35% of theory) of 1-(2,4-dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanol of melting point 88°-90° C. are obtained.

Aufarbeitung

  1. customThe organic phase is separated off
  2. washwashed with three 100 ml portions of saturated sodium chloride solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated
  5. customcrystallizes after the mixture

Quellen und Nachweise

ORD-Eintrag
ord-4bd5082c1bf1429e8c2e90a042b4904b
Quelldatensatz
uspto-grants-1990_05
Patentnummer
US04921870

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