Chlorosuccinimide → 7-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-9-carboxylic acid

HRID 1650367Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1650367
[O:1]1[C:7]2[C:8]([C:12]([OH:14])=[O:13])=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:15]N1C(=O)CCC1=O>CN(C=O)C.C(OCC)(=O)C>[Cl:15][C:10]1[CH:9]=[C:8]([C:12]([OH:14])=[O:13])[C:7]2[O:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]=2[CH:11]=1

Komponenten

5

Edukt 2

HCID 31398ChlorosuccinimideHCID 127011502,3,4,5-Tetrahydro-1-benzoxepin-9-carboxylic acid

Produkt 1

HCID 145020977-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-9-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 1.7 g (8.9 mmol) of 2,3,4,5-tetrahydro-1-benzoxepin-9-carboxylic acid in 5 ml of DMF is added 1.41 g(10.6 mmol) of N-chlorosuccinimide (NCS) in one portion at room temperature. The solution is stirred overnight and then diluted with ethyl acetate and washed with water. The organic layer is then dried (MgSO4), filtered and concentrated to obtain 7-chloro-2,3,4,5-tetrahydro-1-benzoxepin-9-carboxylic acid.

Aufarbeitung

  1. washwashed with water
  2. dry with materialThe organic layer is then dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-bf635fa7ecbc469db7d164f8e9c7fec1
Quelldatensatz
uspto-grants-1990_05
Patentnummer
US04924010

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