2-Pyrazoline → 1-(2,6-Difluorophenylsulphonylcarbamoyl)-2-pyrazoline

HRID 1650992

Reaktionsgleichung

Reaktionsgleichung von HRID 1650992
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH:12][C:13]([NH2:15])=[O:14])(=[O:11])=[O:10].[NH:16]1[CH2:20][CH2:19][CH:18]=N1>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH:12][C:13]([N:15]1[CH2:18][CH2:19][CH:20]=[N:16]1)=[O:14])(=[O:11])=[O:10]

Komponenten

4

Edukt 2

HCID 669622-PyrazolineHCID 53937098N-(2,6-difluorophenylsulphonyl)urea

Produkt 1

HCID 230507491-(2,6-Difluorophenylsulphonylcarbamoyl)-2-pyrazoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

N-(2,6-difluorophenylsulphonyl)urea in an amount of 2.36 and 1.40 g of 2-pyrazoline in 20 ml of dioxane are refluxed for 4 hours. After evaporation of the solvent at reduced pressure, the remaining solid is dissolved in 20 ml of water. This solution is filtrated and acidified with conc. hydrochloric acid. The precipitate is sucked off, washed with water and dried, yielding the title product, viz. 1-(2,6-difluorophenylsulphonylcarbamoyl)-2-pyrazoline in a yield of 1.87 g; melting point 183° C.

Aufarbeitung

  1. customAfter evaporation of the solvent at reduced pressure
  2. dissolutionthe remaining solid is dissolved in 20 ml of water
  3. filtrationThis solution is filtrated
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b18fa86a7df846fa805fdd7829ec0e5a
Quelldatensatz
uspto-grants-1990_05
Patentnummer
US04927452

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