alphahydroxy-N-[1-methyl-4-(3-pyridinyl)butyl]benzeneacetamide → (S)-2-Amino-5-(3-pyridyl)pentane
Reaktionsgleichung
OC(C1C=CC=CC=1)C([NH:5][CH:6]([CH3:16])[CH2:7][CH2:8][CH2:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=O>Cl>[CH3:16][C@H:6]([NH2:5])[CH2:7][CH2:8][CH2:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
As in Example 16, a solution of 16.3 g of [S-(S*,S*)]-alpha-hydroxy-N-[1-methyl-4-(3-pyridinyl)butyl]benzeneacetamide in 160 mL of 6N HCl was heated at reflux for 22 hours. The crude product, obtained by the usual work up was distilled to yield 8.3 g of (S)-alpha-methyl-3-pyridinebutanamine, (bp 85°-87° C./0.1 mm)
Aufarbeitung
- temperatureat reflux for 22 hours
- customThe crude product, obtained by the usual work
- distillationup was distilled
Quellen und Nachweise
- ORD-Eintrag
- ord-997c363a1c724258bf1baede9361b3ac
- Quelldatensatz
- uspto-grants-1990_05
- Patentnummer
- US04927826
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