Isopropyl iodide → Methyl 2-cyano-3-methylbutanoate

HRID 1651279Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1651279
[Na].[C:2]([CH2:4][C:5]([O:7][CH2:8]C)=[O:6])#[N:3].[CH:10](I)([CH3:12])[CH3:11]>CO>[CH:10]([CH:4]([C:2]#[N:3])[C:5]([O:7][CH3:8])=[O:6])([CH3:12])[CH3:11]

Komponenten

5

Edukt 3

HCID 6362Isopropyl iodideHCID 7764Ethyl cyanoacetateHCID 5360545Sodium

Produkt 1

HCID 557651Methyl 2-cyano-3-methylbutanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

In 20 ml of absolute methanol was dissolved 520 mg of metallic sodium, and 2.12 g of ethyl cyanoacetate was added thereto with stirring at room temperature, after which 4.0 of isopropyl iodide was added dropwise over a period of 10 minutes. After completion of the dropwise addition, the resulting mixture was stirred at room temperature for 3 hours, refluxed for 1 hour, subjected to a conventional post-treatment, and then distilled under reduced pressure to obtain 2.1 g of methyl α-isopropylcyanoacetate.

Aufarbeitung

  1. additionwas added
  2. additionAfter completion of the dropwise addition
  3. stirringthe resulting mixture was stirred at room temperature for 3 hours
  4. temperaturerefluxed for 1 hour
  5. distillationdistilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7ae835c1f86d4049a404a509ece65690
Quelldatensatz
uspto-grants-1990_05
Patentnummer
US04927919

Notizen zur Reaktion

Wird geladen…