1-Propanamine, 3-(2-methoxyethoxy)- → 5-(N-methoxyethoxypropylcarbamoyl)thieno[2,3-b]thiophene-2-sulfonamide

HRID 1651510Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1651510
CO[C:3]([C:5]1[S:9][C:8]2[S:10][C:11]([S:13]([NH2:16])(=[O:15])=[O:14])=[CH:12][C:7]=2[CH:6]=1)=[O:4].[CH3:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][CH2:24][NH2:25]>CO>[CH3:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][CH2:24][NH:25][C:3]([C:5]1[S:9][C:8]2[S:10][C:11]([S:13]([NH2:16])(=[O:14])=[O:15])=[CH:12][C:7]=2[CH:6]=1)=[O:4]

Komponenten

4

Edukt 2

HCID 1085741-Propanamine, 3-(2-methoxyethoxy)-HCID 14700202Methyl 5-sulfamoylthieno[2,3-b]thiophene-2-carboxylate

Produkt 1

HCID 147002065-(N-methoxyethoxypropylcarbamoyl)thieno[2,3-b]thiophene-2-sulfonamideAusbeute 64,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

5-Methoxycarbonylthieno[2,3-b]thiophene-2-sulfonamide (0.55 g., 2 mmoles) and 3-(methoxyethoxy)propylamine (0.80 g., 6 mmoles) were refluxed in methanol (5 mL) for 96 hours. The solution was cooled and evaporated in vacuo to remove most of the methanol. Ether was added and the resulting product was recrystallized from 1,2-dichloroethane to give 0.49 g of 5-(N-methoxyethoxypropylcarbamoyl)thieno[2,3-b]thiophene-2-sulfonamide, m.p. 154°-155° C.

Aufarbeitung

  1. temperatureThe solution was cooled
  2. customevaporated in vacuo
  3. customto remove most of the methanol
  4. additionEther was added
  5. customthe resulting product was recrystallized from 1,2-dichloroethane

Quellen und Nachweise

ORD-Eintrag
ord-e735d9f296a140f5a9de6040ffef178b
Quelldatensatz
uspto-grants-1990_05
Patentnummer
US04929549

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