Ethyl 3-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]-propionate → HCID 15055866, Verbindung

HRID 1651558

Reaktionsgleichung

Reaktionsgleichung von HRID 1651558
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]([O:20]CC)=[O:19])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1>[OH-].[Na+].C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH2:12][CH2:11]2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 1

HCID 15055865Ethyl 3-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]-propionate

Produkt 1

HCID 15055866HCID 15055866, VerbindungAusbeute 92,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

1.00 g (2.48 mmol) of ethyl 3-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]propionate obtained in Example 24 was dissolved in a mixed solution of 1 ml of 50 wt % of aqueous sodium hydroxide and 8 ml of ethanol, and the solution was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, neutralized with dil. hydrochloric acid and then extracted with chloroform. The chloroform extract was dried over anhydrous sodium sulfate and then concentrated to give 0.86 g (92%) of 3-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]propionic acid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. extractionextracted with chloroform
  3. extractionThe chloroform extract
  4. dry with materialwas dried over anhydrous sodium sulfate
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-87790da58855434a9fdd1f40c701393b
Quelldatensatz
uspto-grants-1990_05
Patentnummer
US04929618

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