HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
p-Toluenesulfonic acid → 1-Piperidinebutanoic acid, 4-((4-chlorophenyl)-2-pyridinylmethoxy)-, ethyl ester, mono(4-methylbenzenesulfonate)
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | p-Toluenesulfonic acid | HCID 6101 | — |
| Edukt | rac Bepotastine Ethyl Ester | HCID 3079389 | — |
| Produkt | 1-Piperidinebutanoic acid, 4-((4-chlorophenyl)-2-pyridinylmethoxy)-, ethyl ester, mono(4-methylbenzenesulfonate) | HCID 3079388 | 91,4% |
Reaktionsschritte
5.33 g (12.78 mmol) of the ethyl ester obtained in Example 26 and 2.43 g (12.78 mmol) of p-toluenesulfonic acid were treated in the same procedure as described in Example 2 to give 6.88 g (91%) of ethyl 4-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]butanoate p-toluenesulfonate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04929618 |
| Quelldatensatz | uspto-grants-1990_05 |
| ORD ID | ord-4d93dfd2026b4269b89853f5b29f94ef |
| Quellennotiz | uspto-grants-1990_05 |