Methyl iodide → (2RS,4SR)-4-(3-benzyloxyphenyl)-4-methoxy-2-methyltetrahydropyran
Reaktionsgleichung
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]2([OH:22])[CH2:20][CH2:19][O:18][CH:17]([CH3:21])[CH2:16]2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23]I>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]2([O:22][CH3:23])[CH2:20][CH2:19][O:18][CH:17]([CH3:21])[CH2:16]2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
Using the procedure described in Example 3, (2RS,4SR)-4-(3-benzyloxyphenyl)-4-hydroxy-2-methyltetrahydropyran (1.22 g; obtained as described within Note k. below Table IX in Example 44) was reacted with methyl iodide (0.5 ml), to give (2RS,4SR)-4-(3-benzyloxyphenyl)-4-methoxy-2-methyltetrahydropyran (0.84 g, 66%), as an oil.
Quellen und Nachweise
- ORD-Eintrag
- ord-8892728787a3494eaebd13389b816ba4
- Quelldatensatz
- uspto-grants-1995_04