Morpholine → (R)-2-Hydroxy-1-morpholinopropan-1-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of methyl (R)-lactate (104 g) and morpholine (260 ml) was heated for 60 hours at 85° C. The reaction mixture was concentrated under reduced pressure, and the concentrate was purified by means of a silica gel chromatography (silica gel 800 g, eluent: hexane-ethyl acetate=1:1→etyl acetate) to give N-[(2R)-2-hydroxypropionyl]morpholine (141 g) as a pale yellow oily product.

Herkunft & Nachweise