Thionyl Chloride → 4-(Chloromethyl)-2-cyclopropylthiazole hydrochloride

HRID 1654212Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1654212
[CH:1]1([C:4]2[S:5][CH:6]=[C:7]([CH2:9]O)[N:8]=2)[CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[ClH:13].[CH:1]1([C:4]2[S:5][CH:6]=[C:7]([CH2:9][Cl:13])[N:8]=2)[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 20079576(2-Cyclopropylthiazol-4-yl)methanol

Produkt 1

HCID 187591664-(Chloromethyl)-2-cyclopropylthiazole hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

In chloroform (10 ml) was dissolved 2-cyclopropyl-4-hydroxymethylthiazole (0.9 g), to which was added dropwise, under ice-cooling, thionyl chloride (0.68 ml), followed by stirring for 30 minutes at room temperature. Excess thionyl chloride was distilled off under reduced pressure. To the residue was added diethyl ether to yield 2-cyclopropyl-4-chloromethyl thiazole hydrochloride (1.1 g) as pale brown powder. m.p. 108°-110° C.

Aufarbeitung

  1. additionto which was added dropwise, under ice-
  2. temperaturecooling
  3. distillationExcess thionyl chloride was distilled off under reduced pressure
  4. additionTo the residue was added diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-21dbd786b3184c6bb3ae790f12765813
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05405861

Notizen zur Reaktion

Wird geladen…