2-Amino-3-(2-bromobenzyloxy)pyridine → N'-[3-[(2-bromophenyl)methoxy]-2-pyridinyl]-2-phenylethanimidamide

HRID 1654842Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1654842
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Br:16])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl.[C:18]1([CH2:24][C:25](=[NH:29])OCC)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[Br:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:9][O:8][C:7]1[C:2]([NH:1][C:25](=[NH:29])[CH2:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 104688082-Amino-3-(2-bromobenzyloxy)pyridineHCID 12218775Ethyl 2-phenylacetimidate hydrochloride

Produkt 1

HCID 178510792N'-[3-[(2-bromophenyl)methoxy]-2-pyridinyl]-2-phenylethanimidamideAusbeute 3,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-3-(2-bromobenzyloxy)pyridine (5.58 g, 20 mmol) and ethyl phenylacetimidate hydrochloride (4.39 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave a residue which was purified by chromatography (silica, chloroform/methanol) and recrystallisation from ethanol/ether to obtain the product (0.28 g), m.p. 158°-169° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customEvaporation of the solvent
  4. customgave a residue which
  5. customwas purified by chromatography (silica, chloroform/methanol) and recrystallisation from ethanol/ether

Quellen und Nachweise

ORD-Eintrag
ord-0a3816cd36fe4debac1ed2ba97b645ff
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409943

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