Ethyl 2-phenylacetimidate hydrochloride → HCID 178426839, Verbindung

HRID 1654854

Reaktionsgleichung

Reaktionsgleichung von HRID 1654854
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:11]=2[F:17])=[CH:6][CH:5]=[C:4]([CH3:18])[N:3]=1.[ClH:19].[C:20]1([CH2:26][C:27](=[NH:31])OCC)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(O)C>[ClH:19].[F:17][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]([F:16])[C:10]=1[CH2:9][O:8][C:7]1[C:2]([NH:1][C:27](=[NH:31])[CH2:26][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:3][C:4]([CH3:18])=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 12218775Ethyl 2-phenylacetimidate hydrochlorideHCID 200770212-Amino-3-(2,6-difluorobenzyloxy)-6-methylpyridine

Produkt 1

HCID 178426839HCID 178426839, VerbindungAusbeute 6,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-3-(2,6-difluorobenzyloxy)-6-methyl-pyridine (5.0 g, 20 mmol) and ethyl phenylacetimidate hydrochloride (4.39 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil which was purified by chromatography (silica, chloroform/methanol) and recrystallisation from ethanol/ether to obtain the product (0.56 g), m.p. 173°-177° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customEvaporation of the solvent
  4. customgave an oil which
  5. customwas purified by chromatography (silica, chloroform/methanol) and recrystallisation from ethanol/ether

Quellen und Nachweise

ORD-Eintrag
ord-c596973933f0479ebdc3ea97b2ba706f
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409943

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