Ammonia → HCID 178491292, Verbindung

HRID 1654883Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1654883
[CH3:1][O:2][C:3]1[CH:27]=[CH:26][C:6]([CH2:7][O:8][C:9]2[C:10]([NH:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)=S)=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[NH3:28]>>[CH3:1][O:2][C:3]1[CH:27]=[CH:26][C:6]([CH2:7][O:8][C:9]2[C:10]([NH:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)=[NH:28])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 20076976N-(3-(4-Methoxybenzyloxy)pyrid-2-yl)-N'-(4-chlorophenyl)thiourea

Produkt 1

HCID 178491292HCID 178491292, Verbindung

Versuchsvorschrift

A mixture of yellow mercuric oxide (1.05 g, 0.00488 mol), N-[3-(4-methoxybenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (1.5 g, 0.0041 mol)and methanolic ammonia solution (40 ml) was stirred for 2 days at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by trituration with ether and recrystallisation from acetonitrile gave the desired product. Yield 0.96 g (61.5%) m.p. 165°-166 ° C.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent
  4. customfollowed by trituration with ether and recrystallisation from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-6440d4179ae14f97a87a7c8921d3d81d
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409943

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