Ammonia → HCID 178426525, Verbindung

HRID 1654896

Reaktionsgleichung

Reaktionsgleichung von HRID 1654896
[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:28]>>[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)=[NH:28])=[N:8][CH:9]=[CH:10][CH:11]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 20076981N-[3-(2-chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-4-methylphenylthiourea

Produkt 1

HCID 178426525HCID 178426525, Verbindung

Versuchsvorschrift

A mixture of yellow mercuric oxide (0.65g, 0.0025 mol), N-[3-(2-chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-4-methylphenylthiourea (1 .0g, 0.0025 mol) and methanolic ammonia solution (30 ml) was stirred for 3 days at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by recrystallisation from ethanol gave the desired product. Yield 0.55 g, (57%), m.p. 136°-138 ° C.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent
  4. customfollowed by recrystallisation from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-51677125a3b044ab8b63e3c5277b2a30
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409943

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