Ammonia → HCID 178512029, Verbindung

HRID 1654912

Reaktionsgleichung

Reaktionsgleichung von HRID 1654912
[F:1][C:2]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:29]>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:29])=[N:8][CH:9]=[CH:10][CH:11]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 200770093-(2,4,6-Trifluorobenzyloxy)pyrid-2-yl-N'-(4-chlorophenyl)thiourea

Produkt 1

HCID 178512029HCID 178512029, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of yellow mercuric oxide (0.74 g, 0.036 mol), N-[3-(2,4,6-trifluorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (1.27 g, 0.003 mol) and methanolic ammonia solution (40 ml) was stirred for 1 day at room temperature. The solvent was removed-in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent, trituration with ether and recrystallisation from acetonitrile gave the desired product. Yield 0.63 g (52%), m.p. 161°-162 ° C.

Aufarbeitung

  1. filtrationfiltered hot
  2. customEvaporation of the solvent, trituration
  3. customwith ether and recrystallisation from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-cc2ee1dd54d346f69dbe993fe7a9be88
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409943

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