Ammonia → HCID 178491293, Verbindung

HRID 1654918Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1654918
[F:1][C:2]1[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[CH:23][C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:29]>>[F:1][C:2]1[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[CH:23][C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:29])=[N:8][CH:9]=[CH:10][CH:11]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 20076960HCID 20076960, Verbindung

Produkt 1

HCID 178491293HCID 178491293, Verbindung

Versuchsvorschrift

A mixture of yellow mercuric oxide (0.54 g, 0.0025 mol), N-[3-(2-fluoro-4-methoxybenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (0.8 g, 0.0021 mol) and methanolic ammonia solution (40 ml) was stirred for 2 days at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by trituration with ether and recrystallisation from acetonitrile gave the desired product. Yield 0.37 g, (45%), m.p. 158°-161 ° C.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent
  4. customfollowed by trituration with ether and recrystallisation from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-c370e1b3f9aa4682adf1778ba55b39d5
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409943

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