Ammonia → HCID 178512030, Verbindung

HRID 1654929Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1654929
[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=S)=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1.[NH3:29]>>[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[NH:29])=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 20076938HCID 20076938, Verbindung

Produkt 1

HCID 178512030HCID 178512030, Verbindung

Versuchsvorschrift

A mixture of yellow men:uric oxide (0.36 g, 0.0017 mol), N-[3-(2-chloro-6-fluorobenzyloxy)-5-chloropyrid-2-yl]-N'-4-chlorophenylthiourea (0.64 g, 0.0014 mol)and methanolic ammonia solution (20 ml) was stirred for 1 day at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by recrystallisation from ethanol gave the desired product. Yield 0.09 g (15%), m.p. 162°-163 ° C.

Aufarbeitung

  1. additionA mixture of yellow men
  2. customThe solvent was removed in vacuo
  3. filtrationfiltered hot
  4. customEvaporation of the solvent
  5. customfollowed by recrystallisation from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-3507b44652704b43a0079b336444d124
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409943

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