Ammonia → HCID 178426837, Verbindung

HRID 1654932

Reaktionsgleichung

Reaktionsgleichung von HRID 1654932
[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=S)=[N:8][C:9]([CH3:12])=[CH:10][CH:11]=1.[NH3:29]>>[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[NH:29])=[N:8][C:9]([CH3:12])=[CH:10][CH:11]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 20076972N-[3-(2-chloro-6-fluorobenzyloxy)-6-methylpyrid-2-yl]-N'-4-chlorophenylthiourea

Produkt 1

HCID 178426837HCID 178426837, Verbindung

Versuchsvorschrift

A mixture of yellow mercuric oxide (0.58 g, 0.0027 mol), N-[3-(2-chloro-6-fluorobenzyloxy)-6-methylpyrid-2-yl]-N'-4-chlorophenylthiourea (1.00 g, 0.0023 mol) and methanolic ammonia solution (30 ml) was stirred for 2 days at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by recrystallisation from ethanol gave the desired product. Yield 0.52 g (54%), m.p. 148°-149 ° C.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent
  4. customfollowed by recrystallisation from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-bace22611c0a4f2eb2deaa89eade5626
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409943

Verknüpfte Notizen

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