Acetyl chloride → HCID 20077196, Verbindung

HRID 1654951Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1654951
[Cl-].[Al+3].[Cl-].[Cl-].[CH3:5][O:6][C:7](=[O:18])[CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1.[C:19](Cl)(=[O:21])[CH3:20]>C(Cl)Cl>[CH3:5][O:6][C:7](=[O:18])[CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:19](=[O:21])[CH3:20])[CH:15]=2)[CH2:10]1

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 14090225Methyl (2,3-dihydro-1H-inden-2-yl)acetate

Produkt 1

HCID 20077196HCID 20077196, VerbindungAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

160 ml of methylene chloride was added with 52.9 g (0.388 mol) of anhydrous aluminum chloride, and further added with 40 ml of methylene chloride containing 25.03 g (0.132 mol) of methyl(indan-2-yl)acetate under ice-cooling. Subsequently, 13.1 ml (0.185 mol) of acetyl chloride was added thereto dropwise. Stirring was conducted for 40 minutes at the same temperature. The reaction mixture was poured into ice-water and the organic phase was collected. After washing and drying, the solvent was condensed under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2) to obtain 27.8 g of an oily product. Yield: 91%

Aufarbeitung

  1. temperaturecooling
  2. customthe organic phase was collected
  3. washAfter washing
  4. customdrying
  5. customcondensed under reduced pressure
  6. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2)

Quellen und Nachweise

ORD-Eintrag
ord-11aa938d732b4e16bbe408595e14c20b
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409956

Notizen zur Reaktion

Wird geladen…