m-Chloroperbenzoic acid → HCID 20077200, Verbindung

HRID 1654952Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1654952
[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10](C(=O)C)[CH:11]=2)[CH2:6]1.ClC1C=CC=[C:21]([C:25]([O:27]O)=[O:26])C=1>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:27][C:25](=[O:26])[CH3:21])[CH:11]=2)[CH2:6]1

Komponenten

4

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 20077196HCID 20077196, Verbindung

Produkt 1

HCID 20077200HCID 20077200, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

11.0 g (47.0 mmol) of methyl(5-acetylindan-2-yl)acetate was dissolved in 200 ml of methylene chloride, to which was added 14.6 g (67 mmol) of m-chloroperbenzoic acid and stirred for 4 hours at room temperature, followed by refluxing for 17 hours. The reaction mixture was washed with saturated aqueous sodium bicarbonate and water in this order, dried and then the solvent was removed. The residue was purified by silica gel column chromatography (chloroform) to obtain 11.3 g of an oily product. Yield: 97%

Aufarbeitung

  1. temperatureby refluxing for 17 hours
  2. washThe reaction mixture was washed with saturated aqueous sodium bicarbonate and water in this order
  3. customdried
  4. customthe solvent was removed
  5. customThe residue was purified by silica gel column chromatography (chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-fb7ee56e50bc459fa4fa577f5c76189a
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409956

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