Dichloromethane → HCID 18921490, Verbindung

Reaktionsgleichung

C([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([CH2:12][NH:13][S:14]([C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)(=[O:16])=[O:15])[CH2:6]2)=O.[C:24]([CH:29]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:26][CH2:27][CH3:28])=[O:25].[CH2:49](Cl)Cl>>[CH2:27]([O:26][C:24](=[O:25])/[CH:29]=[CH:49]/[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([CH2:12][NH:13][S:14]([C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)(=[O:15])=[O:16])[CH2:6]2)[CH3:28]

Komponenten

Edukt 3

HCID 6344Dichloromethane

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester

HCID 18921503HCID 18921503, Verbindung

Produkt 1

HCID 18921490HCID 18921490, VerbindungAusbeute 77 %

Versuchsvorschrift

To 20 ml of methylene chloride, 1.29 g (3.68 mmol) of 5-formyl-2-[(4-chlorophenyl)sulfonylaminomethyl]indan and 1.28 g (3.68 mmol) of carboethoxymethylene triphenylphosphoran were added and stirred for 16 hours at room temperature. The reaction solution was purified by silica gel column chromatography.(chloroform), and the precipitates obtained were recrystallized from a solvent mixture of ethyl acetate and hexane. 1.18 g of colorless crystals were obtained. Yield: 77%