Thionyl Chloride → HCID 131718192, Verbindung

HRID 1655190Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1655190
[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:13]2[C:18]([Cl:19])=[CH:17][C:16]([C:20]([F:23])([F:22])[F:21])=[CH:15][C:14]=2[Cl:24])[C:7]=1[CH:8]=[CH:9][C:10](O)=[O:11])#[N:2].S(Cl)([Cl:27])=O>C1(C)C=CC=CC=1>[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:13]2[C:18]([Cl:19])=[CH:17][C:16]([C:20]([F:23])([F:21])[F:22])=[CH:15][C:14]=2[Cl:24])[C:7]=1[CH:8]=[CH:9][C:10]([Cl:27])=[O:11])#[N:2]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 67858667HCID 67858667, Verbindung

Produkt 1

HCID 131718192HCID 131718192, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

By the method of Example 7, Step A, 0.96 g (0.0026 mole) of 3-[4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-5-yl]acrylic acid and 1 mL of thionyl chloride were reacted in 20-30 mL of toluene, yielding 0.56 g of 3-[4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-5-yl]acrylic acid chloride as an oil. The nmr spectrum was consistent with the proposed structure and indicated the product to be primarily the trans acrylic acid derivative.

Quellen und Nachweise

ORD-Eintrag
ord-960a30c824454ff288f7e356804bdbe1
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05250504

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