HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonia → m-Nifedipine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonia | HCID 222 | — |
| Edukt | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Edukt | Methyl acetoacetate | HCID 7757 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | m-Nifedipine | HCID 89082 | — |
Reaktionsschritte
A mixture of 75.5 g (0.50 mole) of 3-nitrobenzaldehyde, 116 g (1.00 mole) of methyl acetoacetate and 55 ml (1.50 mole) of 28% ammonia in 150 ml of methanol is heated under reflux for 5 hr.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05250543 |
| Quelldatensatz | uspto-grants-1993_10 |
| ORD ID | ord-f3feaca82fb24df7b0df36f342933841 |
| Quellennotiz | uspto-grants-1993_10 |