1-Propanol → HCID 10569117, Verbindung

Reaktionsgleichung

[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[NH:17][N:16]=[N:15][N:14]=2)=[CH:9][CH:8]=1.C(O)CC.[OH-].[K+].[Br-].[C:28](#[N:31])[CH2:29][CH3:30]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[N:15][N:16]([CH2:30][CH2:29][C:28]#[N:31])[N:17]=2)=[CH:11][CH:12]=1

Komponenten

Edukt 4

HCID 10311-Propanol

HCID 14797Potassium Hydroxide

HCID 19792087HCID 19792087, Verbindung

HCID 178478115HCID 178478115, Verbindung

Produkt 1

HCID 10569117HCID 10569117, Verbindung

Versuchsvorschrift

To a solution made tepid of 10-2 mole of 5-[4-(3-chloro benzyloxy) phenyl] tetrazole in 60 ml of n-propanol containing 10-2 mole of KOH, 1.2×10-2 mole of propionitrile bromide (IIa) is added and the reaction mixture is heated to reflux for 25 hours. After concentration by evaporating the solvent, the residue is taken up in ether, the etherated solution is washed twice with 20 ml of 0.5N aqueous NaOH, then with water, dried and concentrated. After recrystallization in methanol, the expected compound is obtained.