Benzylamine → n-Benzyl-2-hydroxyacetamide

HRID 1655364

Reaktionsgleichung

Reaktionsgleichung von HRID 1655364
C[O:2][C:3](=O)[CH2:4][OH:5].[CH2:7]([NH2:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH2:7]([NH:14][C:3](=[O:2])[CH2:4][OH:5])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

3

Edukt 2

HCID 7504BenzylamineHCID 66774Methyl Glycolate

Produkt 1

HCID 231065n-Benzyl-2-hydroxyacetamide

Versuchsvorschrift

The procedure of 84A was followed with methyl2-hydroxyethanoate (8 g) and benzylamine (10 ml in 30 ml H2O). After one hour material precipitated out of solution. The mixture was stirred overnight, and the solid recovered by filtration to provide 4.12 g of white solid. The solvent was removed from the filtrate by vacuum to provide 4.71 g of material The solid and filtrate were combined and passed over a silica column eluting with a gradient of ethyl acetate to ethyl acetate/methanol (v:v, 1:1). Removal of solvent provided 8 g of white crystal product.

Aufarbeitung

  1. customAfter one hour material precipitated out of solution
  2. filtrationthe solid recovered by filtration

Quellen und Nachweise

ORD-Eintrag
ord-ec00d9d880564a899597fddd08833cd4
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05250542

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