Triethylamine → HCID 19792116, Verbindung

HRID 1655464Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1655464
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(N(CC)CC)C.[C:20](Cl)(=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24]>C(Cl)Cl>[Cl:12][C:9]1[CH:10]=[CH:11][C:2]([NH:1][C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 78878Methyl 2-amino-5-chlorobenzoate

Produkt 1

HCID 19792116HCID 19792116, VerbindungAusbeute 61 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of methyl 2-amino-5-chlorobenzoate (15 g) and triethylamine (12 ml) in methylene chloride (150 ml) was added dropwise, while stirring under ice-cooling, valeryl chloride (10 ml). The mixture was stirred at room temperature for further two hours. The reaction mixture was washed with an aqueous solution of sodium bicarbonate and water, followed by drying. The solvent was distilled off to afford a pale yellow crystals (13.4 g, 61%), m.p. 48-49° C.

Aufarbeitung

  1. temperaturecooling
  2. stirringThe mixture was stirred at room temperature for further two hours
  3. washThe reaction mixture was washed with an aqueous solution of sodium bicarbonate and water
  4. customby drying
  5. distillationThe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-04ad8f63b43543d79bcc5df67637cbab
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05250554

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