2-Chlorobenzimidazole → Hydrochloric Acid

HRID 16557

Reaktionsgleichung

Reaktionsgleichung von HRID 16557
[Cl:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[C@@H:11]1([NH2:21])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:21][C@@H:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][CH2:12]1.[ClH:1]

Komponenten

5

Edukt 2

HCID 785722-ChlorobenzimidazoleHCID 70580741-Aminotetralin, (S)-

Produkt 2

HCID 313Hydrochloric AcidHCID 11623093(S)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-benzo[d]imidazol-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

The title compound was prepared from 2-chlorobenzimidazole and (S)-1,2,3,4-tetrahydro-1-naphthylamine by Procedure A (reflux in toluene for 2 days). The product was purified by preparative LCMS, added HCl and isolated as a HCl salt (white solid, mp 257-258° C.). MS(ES+) m/z 264 ([M+1]+, 100).

Aufarbeitung

  1. customThe product was purified by preparative LCMS
  2. additionadded HCl

Quellen und Nachweise

ORD-Eintrag
ord-e63c02bb260d484daeeb7469e673adba
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737167B2

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