Dicyclohexylcarbodiimide → 2,4-Dimethyl-4-isopropyl-2-oxazolin-5-one

HRID 1655844Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1655844
[C:1]([NH:4][C:5]([CH3:12])([CH:9]([CH3:11])[CH3:10])[C:6]([OH:8])=[O:7])(=O)[CH3:2].C1(N=C=NC2CCCCC2)CCCCC1>C1COCC1>[CH3:2][C:1]1[O:7][C:6](=[O:8])[C:5]([CH3:12])([CH:9]([CH3:11])[CH3:10])[N:4]=1

Komponenten

4

Edukt 2

HCID 10868DicyclohexylcarbodiimideHCID 2338052-Acetamido-2,3-dimethylbutanoic acid

Produkt 1

HCID 146957652,4-Dimethyl-4-isopropyl-2-oxazolin-5-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

2-Acetamido-2,3-dimethylbutyric acid (16 g) is dissolved in THF (200 mL) and dicyclohexylcarbodiimide (DCC, 21.0 g) is added. The mixture is allowed to stir for 16 hours at 25° C. At the end of this time the mixture is filtered and evaporated to dryness. The residue is dissolved in CH2Cl2 (10 mL) and filtered again. Evaporation of the filtrate gives the crude product which is purified by distillation at 0.65 mmHg, having bp 50° C.

Aufarbeitung

  1. filtrationAt the end of this time the mixture is filtered
  2. customevaporated to dryness
  3. dissolutionThe residue is dissolved in CH2Cl2 (10 mL)
  4. filtrationfiltered again
  5. customEvaporation of the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-38b800039dcc41c89b118753c3ec2882
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05252539

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