2,2-Dimethoxypropane → Methyl 1,2,3,4-tetrahydronaphthalene-2-carboxylate

HRID 1656044

Reaktionsgleichung

Reaktionsgleichung von HRID 1656044
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[C:11]([OH:13])=[O:12].[CH3:14]OC(OC)(C)C>CO>[C:11]([CH:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1)([O:13][CH3:14])=[O:12]

Komponenten

4

Edukt 2

HCID 64952,2-DimethoxypropaneHCID 1013701,2,3,4-Tetrahydro-2-naphthoic acid

Produkt 1

HCID 12588372Methyl 1,2,3,4-tetrahydronaphthalene-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

Dissolve 1,2,3,4-tetrahydro-2-naphthoic acid (10 g, 57 mmol) in methanol (100 mL) and add dimethoxypropane (3 mL). Cool to 5° C. and saturate with hydrogen chloride gas. Allow to stand overnight then evaporate the solvent in vacuo. Take the residue up in ethyl ether, wash with saturated sodium hydrogen carbonate and dry (MgSO4). Evaporate the solvent in vacuo and distill to give 2-carbomethoxy-1,2,3,4-tetrahydronaphthalene; bp 90°-96° [email protected] mm Hg).

Aufarbeitung

  1. concentrationsaturate with hydrogen chloride gas
  2. customthen evaporate the solvent in vacuo
  3. washwash with saturated sodium hydrogen carbonate
  4. dry with materialdry (MgSO4)
  5. customEvaporate the solvent in vacuo
  6. distillationdistill

Quellen und Nachweise

ORD-Eintrag
ord-468bb5f1f93a4377951a1538f2606c3e
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05252601

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