Hydrochloric Acid → 4-Fluorobenzimidic acid ethyl ester hydrochloride

HRID 1656517Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1656517
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[ClH:10].[O:11]1CC[CH2:13][CH2:12]1>C(O)C>[ClH:10].[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 145174-Fluorobenzonitrile

Produkt 1

HCID 122821594-Fluorobenzimidic acid ethyl ester hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 4-fluorobenzonitrile (50 g) in tetrahydrofuran (300 mL) and ethanol (60.5 mL) at 0° C. was saturated with anhydrous hydrogen chloride gas and the resulting solution was allowed to stand overnight. The solvent was evaporated and the resulting solid was collected and washed with ether to provide ethyl 4-fluorobenzimidate hydrochloride as a white solid (20 g); NMR: 8.27 (m,2), 7.51 (m,2), 4.63 (q,2), 1.47 (t,3).

Aufarbeitung

  1. customat 0° C.
  2. customThe solvent was evaporated
  3. customthe resulting solid was collected
  4. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-c1a6320558b6436bb8ca96d5073c58a1
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05254558

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