Hydrochloric Acid → 2-amino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole

HRID 1656986Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1656986
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[N:15]([CH3:16])[N:14]=[N:13][N:12]=2)=[CH:8][N:9]=1)(=O)C.Cl>C(O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[N:15]([CH3:16])[N:14]=[N:13][N:12]=2)=[CH:8][N:9]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 157291852-acetylamino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole

Produkt 1

HCID 157291862-amino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazoleAusbeute 48,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-acetylamino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole (2.0 g) in a mixture of ethanol (20 ml) and aqueous 6N-hydrochloric acid (5 ml) was refluxed for 4 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was adjusted to pH 8 using aqueous sodium bicarbonate under ice cooling. The precipitates were collected by filtration, washed with water and the solid was recrystallized from ethanol to give 2-amino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole (0.81 g, yield: 48.5%). mp: 186°-188° C. (dec.)

Aufarbeitung

  1. temperaturewas refluxed for 4 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customthe solid was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-d4e50b2974d64392ac9c6cd44176fc69
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05256675

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