1-(3-Chlorophenyl)piperazine → HCID 12414808, Verbindung

HRID 1657404

Reaktionsgleichung

Reaktionsgleichung von HRID 1657404
Cl[CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[C:11]([CH3:15])=[CH:12][CH:13]=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[C:11]([CH3:15])=[CH:12][CH:13]=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

Komponenten

4

Edukt 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 46254083-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

Produkt 1

HCID 12414808HCID 12414808, VerbindungAusbeute 34,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 2.4 g of 3-(2-chloroethyl)-2,6-dimethy-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed with heating for 30 hours. The reaction mixture was then treated in the same manner as in Example 1, and the obtained crude crystals were recrystallized from isopropyl alcohol to give 1.4 g of the desired compound as pale yellow needles, m.p. 116.5° - 117.5°C.

Aufarbeitung

  1. temperaturewas refluxed
  2. temperaturewith heating for 30 hours
  3. additionThe reaction mixture was then treated in the same manner as in Example 1
  4. customthe obtained crude crystals
  5. customwere recrystallized from isopropyl alcohol

Quellen und Nachweise

ORD-Eintrag
ord-cacede88fdc148cc8f70e8a89c0ca45c
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03960863

Verknüpfte Notizen

Wird geladen…