1-(3-Chlorophenyl)piperazine → HCID 12414855, Verbindung

HRID 1657408

Reaktionsgleichung

Reaktionsgleichung von HRID 1657408
[CH3:1][C:2]1[N:3]=[C:4]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:5]2[C:6](=[O:11])[C:7]=1[CH2:8][CH2:9]Cl.[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[N:3]=[C:4]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:5]2[C:6](=[O:11])[C:7]=1[CH2:8][CH2:9][N:27]1[CH2:26][CH2:25][N:24]([C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([Cl:17])[CH:19]=2)[CH2:29][CH2:28]1

Komponenten

4

Edukt 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 124149402-methyl-3-(2-chloroethyl)-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one

Produkt 1

HCID 12414855HCID 12414855, VerbindungAusbeute 23,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 1.3 g of 2-methyl-3-(2-chloroethyl)-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one, 4.2 g of 1-(m-chlorophenyl)piperazine and 20 ml of toluene was refluxed with heating for 30 hours. After completion of the reaction, the reaction mixture was then treated in the same manner as in Example 8. The crude crystals thus obtained were recrystallized from ethanol to give 0.5 g of the desired compound as pale orangeyellow needles, m.p. 152° - 154°C.

Aufarbeitung

  1. temperaturewas refluxed
  2. temperaturewith heating for 30 hours
  3. customAfter completion of the reaction
  4. additionthe reaction mixture was then treated in the same manner as in Example 8
  5. customThe crude crystals thus obtained
  6. customwere recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-d081f29e65a146458b38aa8691e1d098
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03960863

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