1-(3-Chlorophenyl)piperazine → HCID 12414814, Verbindung

HRID 1657410Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1657410
Cl[CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

Komponenten

4

Edukt 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 124149363-(2-Chloroethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

Produkt 1

HCID 12414814HCID 12414814, VerbindungAusbeute 40,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 2.2 g of 3-(2-chloroethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 4.5 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed for 30 hours. After completion of the reaction, the reaction mixture was then treated in the same manner as in Example 10. The crude crystals thus obtained were recrystallized from a mixture of ethanol and n-hexane to give 1.5 g of the desired compound as pale yellow powders, m.p. 127° - 128°C.

Aufarbeitung

  1. temperaturewas refluxed for 30 hours
  2. customAfter completion of the reaction
  3. additionthe reaction mixture was then treated in the same manner as in Example 10
  4. customThe crude crystals thus obtained
  5. customwere recrystallized from a mixture of ethanol and n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-10bcdedee62d4034959f8c27fc37583e
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03960863

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