Ethyl 2-(4-acetyl-1-piperazinyl)-5,8-dihydro-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate → HCID 12883909, Verbindung

HRID 1658133Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1658133
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:11]=[CH:12][C:13]3[C:19](=[O:20])[C:18]([C:21]([O:23]CC)=[O:22])=[CH:17][N:16]([CH2:26][CH3:27])[C:14]=3[N:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C(=O)([O-])[O-].[Na+].[Na+]>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:11]=[CH:12][C:13]3[C:19](=[O:20])[C:18]([C:21]([OH:23])=[O:22])=[CH:17][N:16]([CH2:26][CH3:27])[C:14]=3[N:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

3

Edukt 1

HCID 12917682Ethyl 2-(4-acetyl-1-piperazinyl)-5,8-dihydro-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate

Produkt 1

HCID 12883909HCID 12883909, VerbindungAusbeute 88,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 10340Sodium CarbonateLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

Ethyl 2-(4-acetyl-1-piperazinyl)-5,8-dihydro-8-ethyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate (5.0 g) was dissolved in 35 ml of a 10% aqueous solution of sodium carbonate by heating at 90°C for 30 minutes. The resulting solution was filtered to remove the insoluble material, and the filtrate was neutralized with acetic acid to give a precipitate which was collected and recrystallized from a mixture of benzene and chloroform. There is obtained 4.1 g of the product, m.p. 298° - 300°C.

Aufarbeitung

  1. filtrationThe resulting solution was filtered
  2. customto remove the insoluble material
  3. customto give a precipitate which
  4. customwas collected
  5. customrecrystallized from a mixture of benzene and chloroform

Quellen und Nachweise

ORD-Eintrag
ord-b9a29f0bb50d409ba8c618809d104884
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03962443

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