7-Aminodeacetoxycephalosporanic acid → 7-Cyanomethylsulfonylacetamido-3-methyl-3-cephem-4-carboxylic acid
Reaktionsgleichung
[CH3:1][C:2]1[CH2:11][S:10][C@@H:5]2[C@H:6]([NH2:9])[C:7](=[O:8])[N:4]2[C:3]=1[C:12]([OH:14])=[O:13].[C:15]([CH2:17][S:18]([CH2:21][C:22](O)=[O:23])(=[O:20])=[O:19])#[N:16]>>[C:15]([CH2:17][S:18]([CH2:21][C:22]([NH:9][CH:6]1[C:7](=[O:8])[N:4]2[C:3]([C:12]([OH:14])=[O:13])=[C:2]([CH3:1])[CH2:11][S:10][C@H:5]12)=[O:23])(=[O:20])=[O:19])#[N:16]Komponenten
3
Versuchsvorschrift
When the t-butyl ester of 7-ADCA is acylated with cyanomethylsulfonylacetic acid by the procedure of Example 5, 7-cyanomethylsulfonylacetamido-3-methyl-3-cephem-4-carboxylic acid is obtained.
Quellen und Nachweise
- ORD-Eintrag
- ord-fa8d4a7b7fad47819aae83e0b4441646
- Quelldatensatz
- uspto-grants-1976_06