Ethanol → tert-Butyl {[1-(ethoxymethyl)piperidin-4-yl]methyl}carbamate

HRID 16582

Reaktionsgleichung

Reaktionsgleichung von HRID 16582
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:3][CH2:2]1.C=O.[C:18](=[O:21])([O-])[O-].[K+].[K+].[CH2:24](O)[CH3:25]>>[CH2:24]([O:21][CH2:18][N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:14])[CH3:13])[CH2:3][CH2:2]1)[CH3:25]

Komponenten

5

Edukt 4

HCID 702EthanolHCID 712FormaldehydeHCID 11430Potassium CarbonateHCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamate

Produkt 1

HCID 67233964tert-Butyl {[1-(ethoxymethyl)piperidin-4-yl]methyl}carbamate

Versuchsvorschrift

To a stirred solution of tert-butyl (piperidin-4-ylmethyl)carbamate (7.0 g, 33 mmol) in ethanol (19 mL), paraformaldehyde (1.2 g, 39 mmol) and potassium carbonate (5.4 g, 39 mmol) were added at ambient temperature. The mixture was stirred at ambient temperature for 4 h. The mixture was filtered and the filter cake was washed with ethanol (50 mL). The volatile components were removed by evaporation to give the title compound 8.9 g (quant.) as a white powder.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. washthe filter cake was washed with ethanol (50 mL)
  3. customThe volatile components were removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-ea6c31155be54dbcb207cf0d781a0ce8
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737163B2

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