Acetone → alpha-(((4,5-Dihydro-1H-imidazol-2-yl)amino)methyl)benzyl alcohol

HRID 1658251

Reaktionsgleichung

Reaktionsgleichung von HRID 1658251
[NH:1]([C:5]1[NH:6][CH2:7][CH2:8][N:9]=1)[N+]([O-])=O.[C:10]1(C)[C:11](C)=[CH:12]C=[CH:14][CH:15]=1.[CH3:18][C:19]([CH3:21])=[O:20]>>[OH:20][CH:19]([C:21]1[CH:12]=[CH:11][CH:10]=[CH:15][CH:14]=1)[CH2:18][NH:1][C:5]1[NH:6][CH2:7][CH2:8][N:9]=1

Komponenten

4

Edukt 3

HCID 180AcetoneHCID 7237O-XyleneHCID 4100422-Nitroamino-2-imidazoline

Produkt 1

HCID 103775alpha-(((4,5-Dihydro-1H-imidazol-2-yl)amino)methyl)benzyl alcohol

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

A mixture of 15.8 parts β-hydroxy-phenyl-amine, 13 parts 2-nitramino-2-imidazoline and 8 parts xylene is stirred and heated for 30 minutes at 160°C. (oil-bath). After cooling the reaction mixtures to a temperature of about 70°C., there are added 40 parts acetone. The whole is filtered warm and after cooling the filtrate to room temperature, the precipicated product is filtered off and dried, yielding 2-(β-hydroxy-phenethyl-amino)-2-imidazoline; m.p. 147°-149°C.

Aufarbeitung

  1. temperatureAfter cooling the reaction
  2. custommixtures to a temperature of about 70°C., there
  3. filtrationThe whole is filtered
  4. temperaturewarm
  5. temperatureafter cooling the filtrate to room temperature
  6. filtrationthe precipicated product is filtered off
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fe7a586bf6fb42289d35e9df3447928a
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03963718

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