Methanol → N-isopropyl-2,3-dihydro-6-benzofuranamine

HRID 1658285Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1658285
[O:1]1[C:5]2[CH:6]=[C:7]([NH2:10])[CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.CO.[CH:13](I)([CH3:15])[CH3:14]>C(N(CC)CC)C>[CH:13]([NH:10][C:7]1[CH:8]=[CH:9][C:4]2[CH2:3][CH2:2][O:1][C:5]=2[CH:6]=1)([CH3:15])[CH3:14]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 6362Isopropyl iodideHCID 123690442,3-Dihydro-1-benzofuran-6-amine

Produkt 1

HCID 21528943N-isopropyl-2,3-dihydro-6-benzofuranamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To a solution of 2.8 g. of 2,3-dihydro-6-benzofuranamine in 150 ml. of methanol is added 18 ml. of isopropyl iodide and 26.5 ml. of triethylamine. The solution is refluxed for 60 hours and then concentrated in vacuo. The resultant oil is extracted repeatedly with diethyl ether. The extracts are combined, filtered through Celite, and the ether removed in vacuo to give an oil of N-isopropyl-2,3-dihydro-6-benzofuranamine.

Aufarbeitung

  1. temperatureThe solution is refluxed for 60 hours
  2. concentrationconcentrated in vacuo
  3. extractionThe resultant oil is extracted repeatedly with diethyl ether
  4. filtrationfiltered through Celite
  5. customthe ether removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a51d9ac27980474b8dd4ba0d8f526425
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03963717

Notizen zur Reaktion

Wird geladen…