Sodium Hydroxide → HCID 21529154, Verbindung

HRID 1658318Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1658318
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][S:8][C:9]2[C:10]([C:15]([O:17]C)=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][S:8][C:9]2[C:10]([C:15]([OH:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:19][CH:20]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 14277622Methyl 3-[[(4-methoxyphenyl)methyl]thio]-2-pyridinecarboxylate

Produkt 1

HCID 21529154HCID 21529154, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 3 g. of methyl 3-(p-methoxybenzylthio)picolinate in 50 ml. of ethanol is added 10 ml. of 20% aqueous sodium hydroxide solution and the mixture is warmed on a steam bath for two hours. The alcohol is evaporated off and the residue is cooled and acidified with dilute hydrochloric acid. The precipitate is filtered off, washed with water, dried and recrystallized from methanol to give 3-(p-methoxybenzylthio)picolinic acid, m.p. 170°-172°C.

Aufarbeitung

  1. customThe alcohol is evaporated off
  2. temperaturethe residue is cooled
  3. filtrationThe precipitate is filtered off
  4. washwashed with water
  5. customdried
  6. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-f3ca85deaeb0490bbe97aa24c2ed272e
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03963733

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