Heptafluorobutyric anhydride → 5-Chloro-3-nitro-2-(heptafluorobutyramido)pyridine

HRID 1658360

Reaktionsgleichung

[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]([NH2:8])=[N:6][CH:7]=1.FC(F)(F)C(F)(F)C(F)(F)C([O:18][C:19](=O)[C:20]([F:29])([F:28])[C:21]([F:27])([F:26])[C:22]([F:25])([F:24])[F:23])=O>>[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]([NH:8][C:19](=[O:18])[C:20]([F:28])([F:29])[C:21]([F:26])([F:27])[C:22]([F:25])([F:24])[F:23])=[N:6][CH:7]=1

Komponenten

Edukt 2

HCID 67643Heptafluorobutyric anhydride

HCID 2241682-Amino-5-chloro-3-nitropyridine

Produkt 1

HCID 203554765-Chloro-3-nitro-2-(heptafluorobutyramido)pyridine

Versuchsvorschrift

5-Chloro-3-nitro-2-aminopyridine is reacted with heptafluorobutyric anhydride to obtain 5-chloro-3-nitro-2-(heptafluorobutyramido)pyridine which when hydrogenated yields 6-chloro-1-hydroxy-2-(heptafluoro-n-propyl)-1H-imidazo(4,5-b)-pyridine.

Quellen und Nachweise

ORD-Eintrag: ord-abc3d37b033e4f2bab050c899d380699
Quelldatensatz: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US03963734

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