3-Trifluoromethylisobutyranilide → Ethyl-N-(3-trifluoromethylphenyl)isobutyrimidate

HRID 1658671

Reaktionsgleichung

Reaktionsgleichung von HRID 1658671
[B-](F)(F)(F)F.[CH3:6][CH2:7][O+](CC)CC.[F:13][C:14]([F:28])([F:27])[C:15]1[CH:16]=[C:17]([CH:24]=[CH:25][CH:26]=1)[NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21]>ClCCl>[CH2:6]([O:23][C:19](=[N:18][C:17]1[CH:24]=[CH:25][CH:26]=[C:15]([C:14]([F:27])([F:28])[F:13])[CH:16]=1)[CH:20]([CH3:22])[CH3:21])[CH3:7]

Komponenten

4

Edukt 2

HCID 1372643-TrifluoromethylisobutyranilideHCID 2723982Triethyloxonium tetrafluoroborate

Produkt 1

HCID 21528116Ethyl-N-(3-trifluoromethylphenyl)isobutyrimidate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

Add a solution of 5.0 g. (0.03 moles) of triethyloxonium fluoborate in 13 ml. of dichloromethane to a solution of 7.3 g. (0.03 moles) of 3'-trifluoromethylisobutyranilide in 60 ml. of dichloromethane and reflux for 20 hours. Remove 50 ml. of dichloromethane and add 150 ml. of dry ether to precipitate out the product of this example as its fluoborate salt, m.p.=95°-100°C.

Aufarbeitung

  1. additionAdd a solution of 5.0 g
  2. customRemove 50 ml
  3. additionof dichloromethane and add 150 ml
  4. customof dry ether to precipitate out the product of this example as its fluoborate salt, m.p.=95°-100°C.

Quellen und Nachweise

ORD-Eintrag
ord-9ca430cf61254486bff17b0e0f712086
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03965176

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