Chenodeoxycholic Acid → Ursocholic acid

HRID 1659376

Reaktionsgleichung

[OH:1][C@@H:2]1[CH2:25][CH2:24][C@@:23]2([CH3:26])[C@H:4]([CH2:5][C@@H:6]([OH:29])[C@@H:7]3[C@@H:22]2[CH2:21][C@H:20]([OH:27])[C@@:19]2([CH3:28])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C@H:12]([CH3:18])[CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH2:3]1.O[C@@H]1CC[C@@]2(C)[C@H](C[C@@H](O)[C@@H]3[C@@H]2CC[C@@]2(C)[C@H]3CC[C@@H]2[C@H](C)CCC(O)=O)C1>>[OH:1][C@@H:2]1[CH2:25][CH2:24][C@@:23]2([CH3:26])[C@H:4]([CH2:5][C@H:6]([OH:29])[C@@H:7]3[C@@H:22]2[CH2:21][C@H:20]([OH:27])[C@@:19]2([CH3:28])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C@H:12]([CH3:18])[CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH2:3]1

Komponenten

Edukt 2

HCID 10133Chenodeoxycholic Acid

HCID 221493Cholic Acid

Produkt 1

HCID 122340Ursocholic acid

Versuchsvorschrift

The procedure of Example 1 is followed except that an equivalent amount of 3α, 7α, 12α-trihydroxy-5β-cholanoic acid (cholic acid) is substituted for the 3α, 7α-dihydroxy-5β-cholanoic acid, to yield 3α, 7β, 12α-trihydroxy-5β-cholanoic acid.

Quellen und Nachweise

ORD-Eintrag: ord-980537ab6f3c4ec3ab875cb070755d14
Quelldatensatz: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04303754

Verknüpfte Notizen

Wird geladen…