5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 178504070, Verbindung

HRID 1659580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1659580
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[O:10][C:9]([CH2:11][N:12]([CH3:14])[CH3:13])=[CH:8][CH:7]=1.[CH3:15][S:16]([N:19]=[C:20](SC)[S:21][CH3:22])(=[O:18])=[O:17]>C(OCC)(=O)C>[CH3:13][N:12]([CH2:11][C:9]1[O:10][C:6]([CH2:5][S:4][CH2:3][CH2:2][NH:1][C:20]([S:21][CH3:22])=[N:19][S:16]([CH3:15])(=[O:18])=[O:17])=[CH:7][CH:8]=1)[CH3:14]

Komponenten

4

Edukt 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 13449843N-[bis(methylsulfanyl)methylidene]methanesulfonamide

Produkt 1

HCID 178504070HCID 178504070, VerbindungAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 5-[[(2-aminoethyl)thio]methyl]-N,N-dimethyl-furanmethanamine (2.97 g) and methylsulphonylcarbonimidodithioic acid, dimethyl ester (4.0 g) in ethyl acetate (250 ml) was refluxed for 18 hours. The mixture was washed with acetic acid (0.126 ml) in water (20 ml) three times, the aqueous extracts combined and the pH adjusted to 9 with 8% aqueous potassium carbonate. The oily suspension was extracted with ethyl acetate (3×125 ml), the combined extracts dried (magnesium sulphate) and evaporated to dryness to give the title compound (4 g) as a yellow oil.

Aufarbeitung

  1. temperaturewas refluxed for 18 hours
  2. washThe mixture was washed with acetic acid (0.126 ml) in water (20 ml) three times
  3. extractionThe oily suspension was extracted with ethyl acetate (3×125 ml)
  4. dry with materialthe combined extracts dried (magnesium sulphate)
  5. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-de4c82e5e4af4da3a24d7afb949ef96c
Quelldatensatz
uspto-grants-1981_12
Patentnummer
US04304780

Notizen zur Reaktion

Wird geladen…