4-Chloro-2-phenylquinazoline → 4-[3-(2-Methoxyphenoxy)-1-pyrrolidinyl]-2-phenylquinazoline

HRID 1659954Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1659954
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=1[O:5][CH:6]1[CH2:10][CH2:9][NH:8][CH2:7]1.Cl[C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=[C:18]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:17]=1>C(O)(C)C>[CH3:1][O:2][C:3]1[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=1[O:5][CH:6]1[CH2:10][CH2:9][N:8]([C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=[C:18]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:17]=2)[CH2:7]1

Komponenten

4

Edukt 2

HCID 809774-Chloro-2-phenylquinazolineHCID 144973553-(2-Methoxyphenoxy)pyrrolidine

Produkt 1

HCID 127960364-[3-(2-Methoxyphenoxy)-1-pyrrolidinyl]-2-phenylquinazoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To a solution containing 150 ml of isopropanol and 4.8 g (0.025 mole) of 3-o-methoxyphenoxypyrrolidine was added, with stirring, 6.15 g (0.025 mole) of 4-chloro-2-phenylquinazoline. The reaction was exothermic and the mixture refluxed for 15 min. The temperature subsided to room temperature and, after standing at room temperature for 11/2 hr, the resulting reaction mixture was filtered. The crystalline solid was recrystallized with isopropanol. Yield of product was 1.9 g, m.p. 142°-144° C.

Aufarbeitung

  1. additionwas added
  2. temperaturethe mixture refluxed for 15 min
  3. customsubsided to room temperature
  4. customafter standing at room temperature for 11
  5. custom2 hr
  6. customthe resulting reaction mixture
  7. filtrationwas filtered
  8. customThe crystalline solid was recrystallized with isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-1afd9a9325fb4804a49344e73644e83a
Quelldatensatz
uspto-grants-1981_12
Patentnummer
US04306065

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