Methyl Isocyanate → N-Methyl-N'-[2-((5-methyl-4-imidazolyl)methylamino)ethyl]urea

Reaktionsgleichung

[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:3]1[N:4]=[CH:5][NH:6][C:2]=1[CH3:1])=[O:15]

Komponenten

Edukt 2

HCID 12228Methyl Isocyanate

HCID 20557710N-(5-methyl-4-imidazolylmethyl)ethylenediamine

Produkt 1

HCID 20557896N-Methyl-N'-[2-((5-methyl-4-imidazolyl)methylamino)ethyl]urea

Versuchsvorschrift

By the procedure of Example 24, N-(5-methyl-4-imidazolylmethyl)ethylenediamine is reacted with methyl isocyanate to give, after concentrating and separating the residue by column chromatography, the title compound.

Aufarbeitung

customto give
concentrationafter concentrating
customseparating the residue by column chromatography

Quellen und Nachweise

ORD-Eintrag: ord-70e10c66731d4a2f91db7b1b63d8256f
Quelldatensatz: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04307101

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