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Hydrochloric Acid → HCID 178490721, Verbindung

HRID 1660792
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1660792
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH2:19][CH2:18][N:17]([S:21]([C:24]4[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=4[O:31][CH3:32])(=[O:23])=[O:22])[C:16]=3[CH:33]=2)=[O:11])=[CH:5][CH:4]=1)#[N:2].[Cl-].[NH4+].[N-:36]=[N+:37]=[N-:38].[Na+].Cl>CN(C)C=O>[NH:36]1[C:1]([C:3]2[CH:4]=[CH:5][C:6]([NH:9][C:10]([C:12]3[CH:13]=[CH:14][C:15]4[O:20][CH2:19][CH2:18][N:17]([S:21]([C:24]5[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=5[O:31][CH3:32])(=[O:23])=[O:22])[C:16]=4[CH:33]=3)=[O:11])=[CH:7][CH:8]=2)=[N:2][N:38]=[N:37]1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 667886204-(5-chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid (4-cyano-phenyl)-amide

Produkt 1

HCID 178490721HCID 178490721, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228
Dimethylformamide
Lösungsmittel

Versuchsvorschrift

A microwave tube was charged with a solution of 4-(5-chloro-2-methoxybenzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid (4-cyano-phenyl)-amide (50 mg, 0.10 mmol) in dimethylformamide (2.0 mL). Ammonium chloride (102 mg, 1.9 mmol) and sodium azide (121 mg, 1.9 mmol) were added and the tube was sealed under an argon atmosphere and irradiated in a microwave oven at a temperature of 155° C. for 35 min. The mixture was then acidified with HCl 1N and extracted three times with ethyl acetate. The combined organic extracts were dried over sodium sulfate and evaporated. The crude was resuspended in dichloromethane and sonicated. Filtration yielded 4-(5-chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid [4-(1H-tetrazol-5-yl)-phenyl]-amide as a white solid, 35 mg (64%), MS (ISP): m/e=525.0, 527.0 (M−H).

Aufarbeitung

  1. customthe tube was sealed under an argon atmosphere
  2. customirradiated in a microwave oven at a temperature of 155° C. for 35 min
  3. extractionextracted three times with ethyl acetate
  4. dry with materialThe combined organic extracts were dried over sodium sulfate
  5. customevaporated
  6. customsonicated
  7. filtrationFiltration

Quellen und Nachweise

ORD-Eintrag
ord-cecd7e35f90447a7a636ebf626c59d4f
Quelldatensatz
uspto-grants-2011_10
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08030308B2

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