HCID 67021600, Verbindung → Methyl 4-amino-2,6-dichlorobenzeneacetate

HRID 1661018Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1661018
[CH3:1][O:2][C:3](=[O:16])[CH2:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([N+:12]([O-])=O)=[CH:7][C:6]=1[Cl:15]>[Ni].CO>[CH3:1][O:2][C:3](=[O:16])[CH2:4][C:5]1[C:6]([Cl:15])=[CH:7][C:8]([NH2:12])=[CH:9][C:10]=1[Cl:11]

Komponenten

4

Edukt 1

HCID 67021600HCID 67021600, Verbindung

Produkt 1

HCID 67021638Methyl 4-amino-2,6-dichlorobenzeneacetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of (2,6-dichloro-4-nitro-phenyl)-acetic acid methyl ester (12.7 g, 47.13 mmol) and Raney Nickel (3 g) in MeOH (500 mL) is stirred for 3.5 h at rt, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford the title compound as a yellow solid: ESI-MS: 232.0/234.0 [M-H]−; tR=3.11 min (System 2).

Aufarbeitung

  1. filtrationThe reaction mixture is filtered through a pad of celite
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-46990c54e8b8406eb274310749497274
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030311B2

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