Stannous chloride dihydrate → 4'-Amino-N-benzylbiphenyl-4-sulfonamide

HRID 1661144Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1661144
O.O.[Sn](Cl)Cl.[CH2:6]([NH:13][S:14]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-])=O)=[CH:25][CH:24]=2)=[CH:19][CH:18]=1)(=[O:16])=[O:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CN(C=O)C>[NH2:29][C:26]1[CH:27]=[CH:28][C:23]([C:20]2[CH:19]=[CH:18][C:17]([S:14]([NH:13][CH2:6][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)(=[O:16])=[O:15])=[CH:22][CH:21]=2)=[CH:24][CH:25]=1

Komponenten

4

Edukt 2

HCID 61436Stannous chloride dihydrateHCID 59694084N-Benzyl-4'-nitrobiphenyl-4-sulfonamide

Produkt 1

HCID 596940884'-Amino-N-benzylbiphenyl-4-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

416.5 mg (1.85 mmol) of tin(II) chloride dihydrate are added to a solution of 136 mg (0.37 mmol) of N-benzyl-4′-nitrobiphenyl-4-sulfonamide (Example 9A) in 2.0 ml, of DMF. After 18 h at room temperature, the reaction mixture is purified by preparative HPLC. The product fractions are concentrated in vacuo and dried under high vacuum. 117 mg (84.3% of theory) of the title compound are obtained.

Aufarbeitung

  1. customthe reaction mixture is purified by preparative HPLC
  2. concentrationThe product fractions are concentrated in vacuo
  3. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ec2f0b27b8f64d4785e4fa21a84dd7eb
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030329B2

Notizen zur Reaktion

Wird geladen…